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Free energy landscape (FEL) is represented as a function of PC1 and PC2. Projections of motions in the phase space at 300 K of RdRp WT−apo, A97V−apo, P323 L−apo, WT−RdV, A97V−RDV, P323L−RDV are shown. The first and second PC modes from the PCA of the backbone carbon atom fluctuations were used.
