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. 2021 Jul 14;9(7):817. doi: 10.3390/biomedicines9070817

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Trimodulin reduces C5a detection in a concentration-dependent manner. Anaphylatoxin binding assay showing different dilutions of trimodulin (green) and IVIg (blue) compared to the formulation buffer control (0, white bars). C5a was generated with zymosan via the AP and its binding to Igs was analyzed. Free C5a was detected by using a commercial C5a ELISA Kit. The amount of unbound C5a was set to 100% in the FB control. Data represent mean + SD from three independent experiments performed in duplicates. AP: alternative complement pathway; FB: formulation buffer; SD: standard deviation; ELISA: enzyme-linked immunosorbent assay.