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. 2021 Jun 23;9(7):719. doi: 10.3390/biomedicines9070719

Figure 2.

Figure 2

Differentially expressed target genes of miR-208b in the hearts of mice with severe heart hypertrophy. (a) Comparison of predicted miR-208b target genes (3′-UTR, miR-walk 2.0) with downregulated genes identified by next-generation whole RNA sequencing (whole-heart WT versus KO, N = 6 animals/group) that revealed 58 common genes. (b) Real-time qRT-PCR for selected genes in additional whole-heart samples of mice with severe heart hypertrophy (N = 15–19 animals/group, * p ≤ 0.05 vs. WT). (c) Real-time qRT-PCR for selected miR-208b target genes in HL-1 cells transfected either with miR-208b mimics or mimic control (N = 3–7 samples/group, * p ≤ 0.05 vs. mimic control).