Figure 1.

At the beginning of 1900, Santiago Ramón y Cajal described the presence of what he considered primitive interstitial neurons in the loose connective tissue of the tunica muscularis of the gut. Half a century later, M.S. Faussone-Pellegrini and L. Thuneberg observed that these cells were not neurons and called them “Interstitial Cells of Cajal (ICCs)”. These type of cells were then found in many other organs. Finally, Faussone-Pellegrini together with L. M. Popescu, proposed, in 2010, to use the term “Telocyte” to indicate an ICLC. Since their identification, TCs have received attention and the number of scientific articles on the topic is growing considerably.