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. 2021 Jul 16;9(7):828. doi: 10.3390/biomedicines9070828

Figure 2.

Figure 2

Anxiety induced by mCRP treatment was not evident in the co-treatment with 8C10 antibody. Six months of exposure to mCRP induced traits of anxiety, as shown by increased latency to enter to the lit area in the dark and light test (a) and increased grooming time in the open-field test (b). 8C10 showed a clear trend toward protecting against anxiety. Values are mean ± SEM (CSF N = 11, mCRP N = 11, mCRP + 8C10 N = 12 and 8C10 N = 10). Statistics: one-way ANOVA showed a trend to significance (a) p = 0.068, (b) p = 0.058; $ p < 0.05 compared to control by Student’s t test.