Skip to main content
. Author manuscript; available in PMC: 2021 Jul 23.
Published in final edited form as: Clin Cancer Res. 2020 Feb 13;26(12):2800–2809. doi: 10.1158/1078-0432.CCR-19-3505

Figure 3: Interpatient variability in BTK synthesis rates.

Figure 3:

A, percent free BTK on day 3 (Peak), day 4 (Trough) and day 5 (Trough + 24 hours). Black line represents the median. Each symbol represents one patient. Red symbols represent qd dosing; blue symbols represent bid dosing. B, Rate of change in percent free BTK per day for all evaluated patients aligned with different baseline factors; red bars represent 200mg qd patients; blue bars represent 100mg bid patients. Range 3.5 – 31.4%. Linear regression was used to calculate slopes for the return of free BTK and to determine the BTK synthesis rate per day. Statistical significance by Wilcoxon matched-pairs signed-rank test between baseline and treatment timepoints, and Wilcoxon rank-sum test between dose groups is indicated: ****P<0.0001.