Table 2.
Pharmacokinetic results after a single 4 g dose of durlobactam in healthy subjects (n = 31)
| Mean ± SD | Coefficient of variation (%) | |
|---|---|---|
| Cmax, ng/ml | 107,942 ± 19,946 | 18.5 |
| Tmax, h | 3.1 ± 0.32 | 10.6 |
| AUC0‐24, h*ng/ml | 413,101 ± 83179 | 20.1 |
| AUC0‐inf, h*ng/ml | 413,346 ± 83177 | 20.1 |
| CL, L/h | 9.9 ± 1.4 | 14.0 |
| Vz, L | 33.6 ± 5.2 | 15.6 |
Abbreviations: AUC0‐24, area under the concentration‐time curve from time 0 to 24 h; AUC0‐inf, area under the concentration‐time curve from time 0 to infinity; CL, total body clearance; Cmax, maximum plasma concentration, Tmax, time to maximum concentration; V z, volume of distribution.