Table 1.
Demographics and clinical characteristics of study cohort
| Demographics and clinical characteristics | Genotype | ||
|---|---|---|---|
| (0) CC | (1) CA | (2) AA | |
| No. of patients | 9 | 7 | 3 |
| Male/Female | 4/5 | 6/1 | 2/1 |
| Weight, kg | 71.5 ± 6.25 | 69.9 ± 7.31 | 73.4 ± 4.54 |
| Male, kg | 72.3 ± 8.89 | 71.7 ± 8.37 | 73.8 ± 7.82 |
| Female, kg | 70.9 ± 9.63 | 59.0 | 72.6 |
| Race | |||
| East Asian | 4 | 5 | 1 |
| South Asian | 2 | 1 | 0 |
| Filipino | 0 | 1 | 1 |
| European | 1 | 0 | 0 |
| Mixed | 2 | 0 | 1 |
| Serum creatinine, mg/dl | 0.716 ± 0.010 | 0.819 ± 0.016 a | 0.844 ± 0.023 a |
| Baseline serum uric acid, mg/dl | 4.62 ± 0.284 | 6.70 ± 0.368 b | 6.07 ± 0.133 |
Weight, serum creatinine, and baseline serum uric acid are reported as average ± standard error. All statistical tests were done using one‐way ANOVA followed by Tukey’s post hoc test for multiple test correction.
Abbreviations: AA, homozygous variant; CA, heterozygous; CC, homozygous reference.
a
Serum creatinine was significantly different between (0) CC and (1) CA (adjusted p value: 2.99 × 10−7) and between (0) CC and (2) AA (adjusted p value: 1.19 × 10−6).
b
Baseline serum uric acid was significantly different between (0) CC and (1) CA (adjusted p value: 5 × 10−4).