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CYP3A4 protein content and activity in human liver microsomes (HLMs). CYP3A4 protein content (panel a) and CYP3A4 metabolic activity (panel b) by CYP3A4 diplotypes: CYP3A4*1/*1 (n = 245), *1/*1G (n = 64), and *1G/*1G (n = 10). All incubations were completed in triplicate. Multivariable linear regression was used to compare protein content and activity between HLMs based on genotype, adjusting for site of sample collection
