TABLE 3.

Multiple linear regression analysis of covariates with log CYP3A4 protein content and log CYP3A4 activity in human liver microsomes, adjusting for variables independently associated with log CYP3A4 protein content and activity

Covariate	β value	Standard error	p value
Log CYP3A4 protein content (pmol/mg protein)
CYP3A4*1G/*1G diplotype	0.12	0.09	0.18
log POR protein content	1.06	0.13	5.0 × 10−14
100*AKR1D1 mRNA content	0.30	0.97	2.5 × 10−3
UW sample collection	0.04	0.06	0.52
100*Age by year	0.34	0.13	0.01
Male	−0.06	0.06	0.10
CYP3A4*22 present	−0.21	0.09	0.03
Log CYP3A4 activity (pmol/mg protein/min)
CYP3A4*1G/*1G diplotype	0.18	0.11	0.12
Log POR protein content	1.33	0.16	1.1 × 10−14
100*AKR1D1 mRNA content	0.27	0.12	2.3 × 10−2
UW sample collection	0.30	0.08	3.7 × 10−4
100*Age by year	0.51	0.16	1.9 × 10−3

Abbreviations: POR, cytochrome P450 oxidoreductase; AKR1D1, aldo‐keto reductase 1D1; UW, University of Washington.