Table 5.
Subgroup analysis on Se effect on Treg in different thyroid function status
| EHT | p value | SHT | p value | Interaction p | |||
|---|---|---|---|---|---|---|---|
| Se group | Control group | Se group | Control group | ||||
| N | 27 | 34 | 16 | 13 | |||
| aTreg, % | 11.39 ± 3.08 | 11.45 ± 3.46 | 0.939 | 12.25 ± 3.69 | 12.08 ± 2.96 | 0.897 | |
| aTreg, %–6 mo | 13.07 ± 3.25** | 11.39 ± 2.90 | 0.037 | 13.41 ± 3.99** | 11.77 ± 2.57 | 0.211 | |
| ΔaTreg, %–6 mo | 1.68 ± 1.11 | −0.07 ± 2.07 | <0.001 | 1.16 ± 1.23 | −0.31 ± 1.97 | 0.030 | 0.720 |
| Helios/Treg, % | 72.48 ± 7.56 | 73.27 ± 7.73 | 0.690 | 73.79 ± 9.75 | 69.43 ± 9.73 | 0.240 | |
| Helios/Treg, %–6 mo | 76.66 ± 7.84* | 73.32 ± 8.57 | 0.123 | 80.46 ± 8.15* | 70.53 ± 9.34 | 0.005 | |
| ΔHelios/Treg, %–6 mo | 4.18 ± 7.81 | 0.05 ± 7.58 | 0.042 | 6.66 ± 7.8 | 1.09 ± 4.83 | 0.027 | 0.668 |
| Helios/aTreg, % | 79.87 ± 4.19 | 81.10 ± 4.65 | 0.241 | 79.86 ± 2.28 | 81.11 ± 3.32 | 0.241 | |
| Helios/aTreg, %–6 mo | 81.79 ± 4.58 | 79.95 ± 4.71 | 0.131 | 85.89 ± 5.24** | 80.0 ± 5.40 | 0.006 | |
| ΔHelios/aTreg, %–6 mo | 2.05 ± 5.42 | −1.15 ± 5.84 | 0.032 | 6.03 ± 6.26 | −1.11 ± 5.41 | 0.003 | 0.134 |
Values in italics are initial values (baseline). Δ = value after treatment − baseline value.
*Statistically significant difference (<0.05), **Statistically significant difference (<0.01) between post‐treatment and baseline in the same group.
Abbreviations: aTreg, activated regulatory T cells; EHT, euthyroid Hashimoto thyroiditis; Se, selenium; SHT, subclinical Hashimoto thyroiditis; Treg, regulatory T cells.