TABLE 1.

Estimate of drug‐drug interaction between vincristine and second drug (dipyridamole, tazarotene, and quetiapine fumarate) in CEM and NALM6 ALL cell‐lines

Drug name	CEM α	CEM p value	NALM6 α	NALM6 p value
Dipyridamole	11.6	2.45 × 10−9	4.45	6.9 × 10−25
Tazarotene	0.945	9.66 × 10−7	1.42	1.43 × 10−11
Quetiapine fumarate	0.787	0.0235	2.33	1.73 × 10−7

Values of α significantly greater than zero indicate synergy and values significantly less than zero indicate antagonism. The p value indicates the significance of the interaction term (α) relative to additive (0) and was determined using a t‐test.

Abbreviation: ALL, acute lymphoblastic leukemia.