TABLE 2.
Estimate of drug‐drug interaction between vincristine and second drug (dipyridamole, tazarotene, and quetiapine fumarate) in hiPSC‐derived neurons
| Drug name | Branches | Processes | Outgrowth | Viability | ||||
|---|---|---|---|---|---|---|---|---|
| α | p value | α | p value | α | p value | α | p value | |
| Dipyridamole | −3.43 | 2.8 × 10−12 | −1.75 | 5.07 × 10−9 | −1.98 | 5.69 × 10−8 | −3.7 | 4.83 × 10−11 |
| Tazarotene | −1.16 | 0.032 | −1.59 | 2.05 × 10− 8 | −1.63 | 2.9 × 10−7 | −0.72 | 0.25 |
| Quetiapine fumarate | −2.29 | 2.22 × 10−7 | −1.25 | 1.47 × 10−4 | −1.67 | 6.32 × 10−6 | −0.007 | 0.99 |
Values of α significantly greater than zero indicate synergy and values significantly less than zero indicate antagonism. The p value indicates the significance of the interaction term (α) relative to additive (0) and was determined using a t‐test.
Abbreviation: hiPSC, human‐induced pluripotent stem cell.