Table 1.

Molecular Biomarkers and Clinical Impact in Wound Healing.

Growth Factors
IGF-1	protein production and cell proliferation and migration
PDGF	cell growth and division and chemotaxis
TGF-β	angiogenesis, fibroblast proliferation, collagen synthesis and deposition, extracellular matrix (ECM) remodeling, tissue remodeling, granulation tissue stimulant and anti-inflammatory mediator
VEGF	angiogenesis and collagen deposition and epithelialization
IGF-1	protein production and cell proliferation and migration
cytokines
CXCL8	angiogenesis, epithelialization, fibroblast migration and inflammatory mediator
IL-6	leukocyte infiltration, angiogenesis, collagen accumulation, anti-inflammatory, granulation tissue stimulant and mitogenic
TNF-α	leukocyte recruitment, cell regulator, ECM synthesis and inflammatory mediator