Table 2.

Studies measuring telomere length/telomerase activity in granulosa cells in PCOS.

Authors	Variable Measured/Method	Population No.	Population Age (Years)	Results
Li et al., 2017 [85]	GTL: PCR GTA: TRAP	(n = 65) PCOS (IVF) (n = 98) Non-PCOS (IVF)	30.3 ± 4.3 31.7 ± 3.8	GTL: shorter in PCOS GTA: no difference Earlier infertility symptoms when shorter TL and lower TA
Wei et al., 2017 [75]	GTL: PCR	(n = 75) PCOS (IVF) (n = 81) Non-PCOS (IVF)	28.36 ± 2.55 28.09 ± 2.26	GTL: longer in PCOS
Pedroso et al., 2020 [82]	GTL: PCR	(n = 43) PCOS (IVF) (n = 67) Non-PCOS (IVF)	33.7 ± 4.1	GTL: no difference GTA: higher in PCOS Similar TA and TL in GV and MI oocytes

GTL, granulosa telomere length; GTA, granulosa telomerase activity; IVF: in vitro fertilization; GV, germinative vesicle; MI, oocyte at the metaphase of the first meiosis division; TRAP, telomere repeat amplification protocol; PCR, polymerase chain reaction.