Table 3.

POF symptoms and long-term conditions [93].

	Clinic and Biologic Symptoms	Long-Term Clinical Consequences
Diagnostic criteria according to ESHRE	Ovarian dysfunction (Oligo-amenorrhea for at least 4 months)	Infertility
	Clinical estrogen deficiency (climacteric syndrome) and sex hormonal dysfunction with: elevated FSH level >25 IU/L on two occasions >4 weeks apart	Urogenital symptoms (vaginal dryness, irritation and itching, sexual disorders) Cognitive dysfunction (memory and concentration problems, increased risk of dementia) Autoimmunity (increased risk of autoimmune disease) Bone alteration (osteopenia, osteoporosis, and increased risk of fracture) Increased all-cause mortality