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. 2021 Jul 14;11(7):1027. doi: 10.3390/biom11071027

Table 2.

Materials commonly used in adhesion prevention and a brief description of possible reasons for efficacy in adhesion prevention. Adapted from [10].

Material Reasoning for Efficacy
Polytetrafluoroethylene (PTFE) Physiologically inert
Low adhesiveness with cells/tissues
Separates damaged surfaces during wound healing without degradation
Biocompatible
Polylactic acid (PLA) No specific binding site with cells/tissues on polymer matrix
Low adhesiveness with cells/tissues
Separates damaged surfaces during wound healing without degradation
Biocompatible (FDA approval for human use in orthopedic and neurosurgical operations)
Biodegradable
Polyethylene glycol (PEG) High mobility and steric stabilization effects in aqueous solution
Low adhesiveness with cells/tissues
Biocompatible
PLA-PEG Low adhesiveness with cells/tissues
Flexible and hydrophilic
Biocompatible
Biodegradable
Hyaluronic Acid (HA) Wound healing properties
High viscosity when dissolving by water or body fluid
Muco-adhesive property in solid state
Biocompatible
Bioresorbable
Alginate (ALG) Wound healing properties
Muco-adhesive property in solid state
Partially crosslinking by multi-valence positive charged ions in body fluid
Biocompatible
Bioresorbable
Cellulose (oxidized regenerated) (ORC) Wound healing properties, in terms of re-epithelialization
Muco-adhesive property in solid state
Biocompatible
Bioresorbable
Carboxymethyl cellulose (CMC) Remained on the injury surfaces during wound healing
Muco-adhesive property in solid state
Delayed bioresorption
Biocompatible
Icodextrin Metabolized into oligosaccharides by the α-amylase in the body
Delayed bioresorption in peritoneal cavity
Remained on the injury surfaces during wound healing
Biocompatible