Table 1.
Summary of the recent evidence of DFPCs with scaffolds in regeneration medicine.
| Scaffolds | Tissue Regeneration | Origin | Transplantation Model | Reference |
|---|---|---|---|---|
| hydroxyapatite (HA) powder | Fibrous tissues and cementum-like matrix | Bovine | SCID mice subcutaneous pockets |
Handa et al. 2002 [108] |
| HA-coated dental implant | Bone-like and PDL tissues | Murine | Mice tooth-loss model |
Oshima et al. 2014 [88] |
| HA ceramic discs | Cement/woven bone-like tissues | Human | Immunocompromised rats subcutaneous pockets |
Yagyuu et al. 2010 [9] |
| HA/collagen-gel | Acellular cementum-like tissues | Human | SCID mice subcutaneous pockets |
Shinagawa-Ohama et al. 2016 [109] |
| HA/tricalcium phosphate particles | Bone-like tissues | Human | Immunodeficient mice subcutaneous pockets |
Um et al. 2018 [74] |
| Collagen nanohydroxyapatite/phosphoserine biocomposite cryogel | Bone-like tissues | Human | Immunodeficient mice subcutaneous pockets |
Salgado et al. 2020 [78] |
| Treated dentin matrix (TDM) | Periodontal-like tissues | Canine | Canine one-wall periodontal intrabony defects |
Yang et al. 2019 [110] |
| TDM | Root-like tissues | Rat | Rats alveolar fossa |
Guo et al. 2012 [99] |
| TDM | Dentin-like tissues | Human | Immunodeficient mice subcutaneous pockets |
Tian et al. 2015 [96] |
| TDM | Periodontal-like tissues | Human | Nude mice subcutaneous pockets |
Guo et al. 2013 [92] |
| TDM | Root-like tissues | Human | Immunodeficient mice subcutaneous pockets |
Yang et al. 2012 [98] |
| Extracellular matrix | Bone-like tissues | Porcine | Immunocompromised rats critical size parietal defect |
Tsuchiya et al. 2010 [86] |
| Dentin non-collagenous proteins (dNCPs) | Cementum-like tissues | Rat | Rats renal capsules |
Wu et al. 2008 [91] |
| Ceramic bovine bone | Cementum-PDL complex | Human | Nude mice subcutaneous pockets |
Guo et al. 2012 [111] |
| Titanium implants with hydroxyapatite (TiHA), with silicatitanate (TiSiO2) | Enhanced osteogenic differentiation capabilities | Human | In vitro | Lucaciu et al. 2015 [112] |
| Fuoride nanosilicate platelets (NS+F) | Enhanced osteogenic differentiation capabilities | Human | In vitro | Veernala et al. 2019 [113] |
| Graphene-oxide (GO), Thermally reduced graphene oxide (TRGO), Nitrogen-doped graphene (N-Gr) | low levels of cytotoxicity and mitochondria induced damage | Human | In vitro | Olteanu et al. 2015 [114] |