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. 2021 Jul 16;11(7):1045. doi: 10.3390/biom11071045

Figure 3.

Figure 3

Schematic structure of ObR isoforms. Six isoforms of ObR (ObRa to ObRf) have been identified. ObR is divided into three domains: extracellular (ObR extracellular), transmembrane (ObR Transmembrane), and cytoplasmic tail (ObR Intracellular). All isoforms share the same extracellular domain that consists of an N-terminal domain (NTD), two cytokine receptor homology domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two membrane-proximal fibronectin type III (FN III) domains. The long isoform ObRb has an extended C-terminal domain with three tyrosine residues (Y985, Y1077, and Y1138) [62]. Short forms (ObRa, ObRc, ObRd, and ObRf) have shorter C-terminal regions. ObRe is a soluble variant [63].