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Schematic representation of leptin sequence showing the positions of the main studied mutations. Leptin antagonists L39A/D40A/F41A, L39A/D40A/F41A/I42A and S120A/T121A are the result of alanine mutagenesis of residues LDF (amino acids 39–41), LDFI (amino acids 39–42), and ST (amino acids 120–121) respectively. D23L, D40N, S127D, and R128Q are other important mutations that affect leptin biological activity.
