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. 2021 Jul 14;11(7):1024. doi: 10.3390/biom11071024

Table 2.

Selected clinical parameters of patients with colorectal cancer and the NQO1 609C > T genotype.

Clinical Parameters Genotype n (%) p
CC CT TT
pT
Tis 10 (3.6%) 0 (0.0) 0 (0.0)
T1 0 (0.0) 0 (0.0) 0 (0.0) 0.04
T2 12 (4.3%) 10 (3.6%) 0 (0.0%)
T3 115 (41.2%) 50 (17.9%) 11 (3.9%)
T4 50 (17.9%) 15 (5.4%) 6 (2.2%)
pN
N0 113 (40.5%) 28 (10.0%) 0 (0.0) 0.19
N1 40 (14.3%) 26 (9.3%) 10 (3.6%)
N2 34 (12.2%) 21 (7.5%) 7 (2.5%)
M
M0 140 (50.1%) 60 (21.5%) 9 (3.2%) 0.03
M1 47 (16.8%) 15 (5.4%) 8 (2.9%)
Tumor location
•sigmoid colon 80 (29.7%) 16 (5.7%) 0 (0.0)
•cecum and ascending colon 63 (22.6%) 15 (5.4%) 0 (0.0) 0.04
•rectum 28 (10.0%) 15 (5.4%) 9 (3.2%)
•transverse colon 6 (2.2%) 25 (9.0%) 8 (2.9%)
•descending colon 10 (3.6%) 4 (1.4%) 0 (0.0)

Tis: carcinoma in situ, T1: tumor invades submucosa, T2: tumor invades muscularis propria, T3: tumor invades through the muscularis propria into pericolorectal tissues, T4: tumor penetrates to the surface of the visceral peritoneum, N0: no regional lymph node metastasis, N1: metastasis in 1–3 regional lymph nodes, N2: metastasis in 4 or more regional lymph nodes, M0: no distant metastasis, M1: metastasis to distant organs.