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Screening and discovery of HSP47 small molecular inhibitors. Collagen fibril formation was measured in the absence (a) and presence (b) of HSP47. Collagen fibril formation was monitored at 313 nm in phosphate buffer. Inhibition effect of Com II (c), Hs1 (d), and Hs55 (e) against HSP47 in turbidity assay. (f) The binding activity of Hs1 against HSP47 in the label-free MST experiment.
