Table 4.
Sesquiterpene-based, chromane/chromene and flavone derived meroterpenoids.
| Compounds | Source | Activities | Ref. |
|---|---|---|---|
| Langcoquinone A (248) | Spongia sp. | Antimicrobial effects: Staphylococcus aureus = MIC 12.5 μM; Bacillus subtilis = MIC 12.5 μM | [82] |
| Langcoquinone B (249) | Spongia sp. | Antimicrobial effects: Staphylococcus aureus = MIC 12.5 μM; Bacillus subtilis = MIC 12.5 μM | [82] |
| Langconol A (250) | Antimicrobial effects: B. subtilis MIC 12.5 μM | [83] | |
| Langconol C (252) | Antimicrobial effects: B. subtilis = MIC 25.0 μM | [83] | |
| Langcoquinone C (253) | Antimicrobial effects: Staphylococcus aureus = MIC 12.50 μM; Bacillus subtilis = MIC 6.25 μM | [83] | |
| Aminoquinone (257) | Dysidea sp. | Antimicrobial effects: B. subtilis = MIC 50.0 μg/mL; S. aureus = MIC 50.0 μg/mL; E. coli = MIC 50.0 μg/mL | [84] |
| Nakijinol G (267) | Hyrtios sp. | Enzyme Inhibition: PTP1B = IC50 4.8 μM | [87] |
| Dysivillosin A (270) | Dysidea villosa | Enzyme Inhibition: β-hexosaminidase = IC50 8.2 μM | [88] |
| Dysivillosin B (271) | Enzyme Inhibition: β-hexosaminidase = IC50 10.2 μM | [88] | |
| Dysivillosin C (272) | Enzyme Inhibition: β-hexosaminidase = IC50 19.9 μM | [88] | |
| Dysivillosin D (273) | Enzyme Inhibition: β-hexosaminidase = IC50 16.2 μM | [88] | |
| Chartarolide A (274) | Niphates recondite | Cytotoxic effects: HCT-116 = IC50 1.9 μM; HepG2 = IC50 1.8 μM; BGC-823 = IC50 1.3 μM; NCI-H1650 = IC50 5.5 μM; A2780 = IC50 1.5 μM; MCF7 = IC50 1.4 μM | [90] |
| Chartarolide B (275) | Niphates recondite | Cytotoxic effects: HCT-116 = IC50 2.3 μM; HepG2 = IC50 2.8 μM; BGC-823 = IC50 1.6 μM; NCI-H1650 = IC50 4.8 μM; A2780 = IC50 3.2 μM; MCF7 = IC50 3.8 μM | [90] |
| Chartarolide C (276) | Niphates recondite | Cytotoxic effects: HCT-116 = IC50 7.8 μM; HepG2 = IC50 8.9 μM; BGC-823 = IC50 5.4 μM; NCI-H1650 = IC50 11.3 μM; A2780 = IC50 12.5 μM; MCF7 = IC50 8.7 μM | [90] |
| Terretonin N (304) | Nocardiopsis sp. | Antimicrobial effects: S. warneri = IZ 14 mm E. coli = IZ 8 mm | [98] |
| Rubiginosin A (306) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 16.15 μM; HCT116 = IC50 15.56 μM; SK-HEP-1 = IC50 13.80 μM; HL-60 = IC50 12.84 μM | [101] |
| Rubiginosin B (307) | Rhododendron rubiginosum | Cytotoxic effects: HCT116 = IC50 65.72 μM; SK-HEP-1 = IC50 84.66 μM | [101] |
| Rubiginosin C (308) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 40.45 μM; HCT116 = IC50 17.43 μM; SK-HEP-1 = IC50 26.26 μM; HL-60 = IC50 16.44 μM | [101] |
| Rubiginosin D (309) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 49.18 μM; HCT116 = IC50 32.17 μM; SK-HEP-1 = IC50 13.66 μM; HL-60 = IC50 40.07 μM | [101] |
| Rubiginosin E (310) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 38.90 μM; HCT116 = IC50 38.90 μM; SK-HEP-1 = IC50 38.90 μM; HL-60 = IC50 38.90 μM | [101] |
| Rubiginosin F (311) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 38.90 μM; HCT116 = IC50 38.90 μM; SK-HEP-1 = IC50 38.90 μM; HL-60 = IC50 38.90 μM | [101] |
| Rubiginosins G (312) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 38.90 μM; HCT116 = IC50 38.90 μM; SK-HEP-1 = IC50 38.90 μM; HL-60 = IC50 38.90 μM | [101] |
| Anthopogochromene A (313) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 38.90 μM; HCT116 = IC50 38.90 μM; SK-HEP-1 = IC50 38.90 μM; HL-60 = IC50 38.90 μM | [101] |
| Anthopogochromene B (314) | Rhododendron rubiginosum | Cytotoxic effects: A549 = IC50 38.90 μM; HCT116 = IC50 38.90 μM; SK-HEP-1 = IC50 38.90 μM; HL-60 = IC50 38.90 μM | [101] |
| Isopolycerasoidol (315) | Sargassum siliquastrum | Antioxidant effects: DPPH = EC50 8.23 μM; ABTS = EC50 2.33 μM | [103] |
| Sargachromanol D (316) | Sargassum siliquastrum | Antioxidant effects: DPPH = EC50 26.35 μM; ABTS = EC50 4.84 μM | [103] |
| Sargachromanol E (317) | Sargassum siliquastrum | Antioxidant effects: DPPH = EC50 23.84 μM; ABTS = EC50 4.57 μM | [103] |
| Sargachromanol G (318) | Sargassum siliquastrum | Antioxidant effects: DPPH = EC50 33.43 μM; ABTS = EC50 4.05 μM | [103] |
| Sargachromanol I (319) | Sargassum siliquastrum | Antioxidant effects: DPPH = EC50 32.83 μM; ABTS = EC50 6.86 μM | [103] |