Table 2.
Results of the FBAT on ADHD endophenotypes in 113 nuclear families from an African-descent community.
| Coding a | Chr | Marker | Gene | Position b | FBAT Results | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Allele | Cohort | PFBAT (NIF) | ||||||||
| Frequency | Additive | Dominant | Recessive | HA | ||||||
| T44 | 11 | rs916457 | DRD4 | 637,014 | T | 0.050 | 0.026 (27) | 0.025 (27) | ||
| C | 0.950 | 0.025 (27) | ||||||||
| T46 | 4 | rs10001410 | ADGRL3 | 62,474,229 | A | 0.327 | 0.047 (54) | |||
| C | 0.673 | 0.047 (54) | ||||||||
| T47 | 4 | rs1565902 | ADGRL3 | 62,408,620 | C | 0.495 | 0.014 (65) | |||
| T | 0.505 | 0.014 (65) | ||||||||
| 5 | rs2282794 | FGF1 | 141,981,709 | G | 0.542 | 0.041 (32) | ||||
| A | 0.458 | 0.041 (32) | ||||||||
| T48 | 5 | rs2282794 | FGF1 | 141,981,709 | G | 0.542 | 0.004 (64) | 1.9 × 10−4 (32) | ||
| A | 0.458 | 0.004 (64) | 1.9 × 10−4 (32) | |||||||
| T49 | 11 | rs916457 | DRD4 | 637,014 | C | 0.950 | 0.005 (27) | 0.005 (27) | ||
| T | 0.050 | 0.005 (27) | 0.005 (27) | |||||||
| 5 | rs2282794 | FGF1 | 141,981,709 | G | 0.542 | 0.006 (32) | ||||
| A | 0.458 | 0.006 (32) | ||||||||
| T52 | 5 | rs2282794 | FGF1 | 141,981,709 | G | 0.542 | 0.005 (64) | |||
| A | 0.458 | 0.005 (64) | ||||||||
a Refers to subtests of the Wechsler Intelligence Scale for Children, 3rd Edition (WISC-III), and the Wechsler Adult Intelligence Scale, 3rd Edition (WAIS-III) batteries used Cervantes-Henriquez et al. [49]. T44: Total punctuation of the digit span (forward and backward); T46: Comprehension; T47: Arithmetic; T48: Similarities (analogies); T49: Figure completion and T52: Object assembly. See Table 1 for more details. b UCSC GRCh37/hg19 coordinates. Chr: Chromosome; HA: Heterozygous advantage; NIF: Number of informative families; FBAT: Family-based association test; PFBAT: p-value from the FBAT. For interpretation purposes, p-values in bold are statistically significant at 5% after correction for multiple testing using Bonferroni’s method.