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. 2021 Jul 13;11(7):1020. doi: 10.3390/biom11071020

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic illustration of ChAdOx1 nCoV-19 and Ad26.COV2.S constructs and the potential association of tPA and thrombocytopenia. Both ChAdOx nCoV-19 and Ad26.COV2.S contain the tPA leader sequence and the full-length SARS-CoV-2 protein. Ad26.COV2.S additionally has a mutated furin site. The translation of only the tPA leader sequence is unlikely to cause thrombocytopenia as previously reported in ischemic stroke and acute myocardial infarction patients treated with recombinant tPA. Figure was created with Biorender.