Table 3.
Pharmacokinetics and drug-likeness properties of Centipeda minima extract (CMX).
| Arnicolide C | Arnicolide D | Brevilin A | Microhelenin C | |
|---|---|---|---|---|
| Pharmacokinetics | ||||
| GI absorption | High | High | High | High |
| CYP1A2 inhibitor | No | No | No | No |
| CYP2C19 inhibitor | No | No | No | No |
| CYP2C9 inhibitor | No | No | No | No |
| CYP2D6 inhibitor | No | No | No | No |
| CYP3A4 inhibitor | No | No | No | No |
| Log Kp (cm/s) | −6.81 | −6.86 | −6.78 | −6.78 |
| Drug-likeness | ||||
| Lipinski | 0 | 0 | 0 | 0 |
| Ghose | 0 | 0 | 0 | 0 |
| Veber | 0 | 0 | 0 | 0 |
| Egan | 0 | 0 | 0 | 0 |
| Muegge | 0 | 0 | 0 | 0 |
| Bioavailability score | 0.55 | 0.55 | 0.55 | 0.55 |