Table 1:
Baseline characteristics of SPS3 Study participants aged 65 years or older by randomized blood pressure target group
| Lower BP target n = 618 |
Higher BP target n = 645 |
P-value | |
|---|---|---|---|
| Demographics | |||
| Age (years, mean±SD) | 73.9±6.0 | 73.7±5.9 | 0.46 |
| Female (n, %) | 266 (43) | 239 (37) | 0.03 |
| Race/ethnicity (n, %) | |||
| White | 352 (57) | 361 (56) | 0.76 |
| Hispanic | 205 (33) | 210 (33) | |
| Black | 51 (8) | 59 (9) | |
| Other | 10 (2) | 15 (2) | |
| Education (n, %) | |||
| 0–8 years | 398 (27) | 392 (26) | 0.90 |
| 9–12 years | 565 (38) | 581 (38) | |
| >12 years | 538 (36) | 546 (36) | |
| Cardiovascular risk factors | |||
| Blood pressure (mmHg, mean±SD) | |||
| Systolic | 144.4±19.3 | 143.7±18.3 | 0.47 |
| Diastolic | 75.2±9.9 | 76.2±10.1 | 0.08 |
| Body-mass index (kg/m2, mean±SD) | 27.6±5.6 | 27.8±5.0 | 0.41 |
| History of hypertension (n, %) | 475 (77) | 499 (77) | 0.83 |
| Diabetes mellitus (n, %) | 217 (35) | 194 (30) | 0.06 |
| Previous stroke or TIA (n, %) | 91 (15) | 95 (15) | 0.99 |
| History of ischemic heart disease | 59 (10) | 81 (13) | 0.09 |
| Current smoking (n, %) | 73 (12) | 59 (9) | 0.12 |
| CKD (eGFR < 60ml/min; n, %) | 155 (25) | 150 (23) | 0.45 |
| Medication | |||
| ACE inhibitors / AT2 antagonists | 417 (67) | 420 (65) | 0.38 |
| Calcium-channel blockers | 145 (23) | 152 (24) | 0.97 |
| Beta blockers | 145 (23) | 149 (23) | 0.88 |
| Diuretics | 199 (32) | 230 (36) | 0.20 |
| Other antihypertensive medications | 49 (8) | 51 (8) | 0.99 |
| Statin (n, %) | 413 (67) | 440 (68) | 0.60 |
| Modified Rankin stroke disability score (n, %) | |||
| 0 | 106 (17) | 101 (16) | 0.70 |
| 1 | 311 (50) | 346 (54) | |
| 2 | 130 (21) | 129 (20) | |
| 3 | 71 (11) | 69 (11) | |
| White Matter Hyperintensities (ARWMC score, n, %) | |||
| None/mild | 244 (40) | 213 (34) | 0.05 |
| Moderate | 196 (32) | 208 (33) | |
| Severe | 169 (28) | 206 (33) | |
| Barthel ADL limitations (n, %) | |||
| No limitations | 390 (63) | 432 (67) | 0.15 |
| 1+ limitations | 228 (37) | 213 (33) |
Abbreviations: ADL, activities of daily living; ARWMC, age-related white matter changes; BP, blood pressure; CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; n, number; SD, standard deviation