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. 2021 Jul 23;10(1):107–120. doi: 10.1016/S2213-2600(21)00157-0

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Published by Elsevier Ltd.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Proposed research schema to advance precision medicine pharmacotherapy in acute respiratory distress syndrome

*Phase 2 and 3 trials might use a platform design if multiple candidate therapies are deemed ready for testing and amenable to a platform. Other trial designs might also be considered. The number of simultaneous arms need not be constant and might depend on resources, enrolment rate, and number and priority of candidate treatments, among other factors. †Biomarker signatures are denoted by coloured arrows.