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. 2021 Jul 9;11:630675. doi: 10.3389/fonc.2021.630675

Table 1.

Univariate analysis of the risk factors for lymph node metastasis in early and advanced gastric cancer.

Risk factor Early (n = 605) Advanced (n = 1561)
n LNM (+) P n LNM (+) P
Sex
 Male 374 63 (16.8%) 1121 839 (74.8%)
 Female 231 46 (19.9%) 0.34 440 319 (72.5%) 0.341
Age (years)
 <65 411 75 (18.2%) 816 606 (74.3%)
 ≥65 194 34 (17.5%) 0.829 745 552 (74.1%) 0.939
Tumor size (cm)
 ≤2 392 47 (12.0%) 127 55 (43.3%)
 >2 213 62 (29.1%) <0.001 1434 1103 (76.9%) <0.001
T
 T1a 269 17 (6.3%)
 T1b 320 90 (28.1%)
 T2 289 127 (43.9%)
 T3 270 197 (73.0%)
 T4 <0.001 1002 834 (83.2%) <0.001
Excluded 16 2 (12.5%)
 M
 M0 1553 1151 (74.1%)
 M1 8 7 (87.5%) 0.688
Pathological type
 SRCC 60 6 (10%) 61 50 (82.0%)
 DC 335 54 (16.1%) 648 435 (67.1%)
 UDC 210 49 (23.3%) 0.024 852 673 (79.0%) <0.001
Pure/mixed
 Pure 291 36 (12.4%) 788 570 (72.3%)
 Mixed 314 73 (23.2%) <0.001 773 588 (76.1%) 0.092
Total 605 109 (18.0%) 1561 1158 (74.2%)

DC, differentiated carcinoma; UDC, undifferentiated carcinoma; SRCC, signet ring cell carcinoma; PEarly SRCC vs. DC=0.224, PEarly DC vs. UDC=0.036, PEarly SRCC vs. UDC=0.024, PAdvanced SRCC vs. DC=0.017, PAdvanced DC vs. UDC <0.001, PAdvanced SRCC vs. UDC=0.580.