FIGURE 3.

The model equations for interactions within a single target lesion. Five species interact in a well‐mixed volume: tumor cells (T), activated CD8 T cells (aCTL), inactive CD8 T cells (iCTL), helper cells (H), and regulatory cells (R), as shown in Figure 1. Therapy effect is turned on or off using switch parameters (${\mathrm{Rx}}_{\mathrm{apd}1},{\mathrm{Rx}}_{\mathrm{actla}4}$) and the therapy effect is modeled as affecting various rates (${\mathrm{Rx}}_{\mathrm{apd}1\_\mathrm{pdl}1}^{\mathrm{eff}}$: decreases rate of conversion from iCTL to aCTL, ${\mathrm{Rx}}_{\mathrm{apd}1}^{\mathrm{eff}}$: increases killing rate, infux rate into TME of aCTL, ${\mathrm{Rx}}_{\mathrm{actla}4}^{\mathrm{eff}\_\mathrm{ctl}},{\mathrm{Rx}}_{\mathrm{actla}4}^{\mathrm{eff}\_\mathrm{h}},{\mathrm{Rx}}_{\mathrm{actla}4}^{\mathrm{eff}\_\mathrm{r}}$: respectively, increase influx rate into TME of aCTL, H and R). H_eff_C and R_Eff_C, are functions capturing saturating effect of H and R on aCTL, and CTL effect on H and R are captured by CTL_eff_H, CTL_eff_R (details in Supplementary section titled: “Role of immune cells in the model of target lesion”)