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. 2021 Jul 9;12:638763. doi: 10.3389/fimmu.2021.638763

Figure 2.

Figure 2

Genomic profiles of the NSCLC patients in the MSKCC (A) and TCGA (B) cohorts. The top 20 genes with the highest mutation frequencies and the corresponding clinical information are shown in the figure. The top five genes with the highest mutation frequencies in the MSKCC cohort were TP53, KRAS, KEAP1, STK11 and PTPRD. The top five genes with the highest mutation frequencies in the TCGA cohort were TP53, TTN, MUC16, CSMD3 and RYR2. The mutation types are indicated as follows: yellow indicates splice sites, blue indicates missense mutations, orange indicates frameshift mutations, green indicates inframe insertions/deletions, and brown indicates nonsense mutations. The clinical characteristics are shown as patient annotations. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; Mann-Whitney U test).