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. 2021 Jul 9;12:638763. doi: 10.3389/fimmu.2021.638763

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Copyright © 2021 Li, Wang, Li, Feng, Hu and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Comparison of the proportions of immune cells estimated by the CIBERSORT method between the high-mutated and low-mutated NOTCH groups in the TCGA-NSCLC cohort. (B) Correlations between the number of NOTCH signaling mutations and the proportions of each immune cell type. (C) Comparison of the Th2 signature between the high-mutated and low-mutated NOTCH groups in the TCGA-NSCLC cohort. (D) Comparison of the expression levels of immune-related genes between the high-mutated and low-mutated NOTCH groups in the TCGA-NSCLC cohort. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; Mann-Whitney U test). NS, not significant.