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. 2021 Jul 16;2021:5529430. doi: 10.1155/2021/5529430

Figure 3.

Figure 3

miR-218-5p and miR-363-3p promoted mesenchymal-endothelial transition in CFs. (a) A phagocytosis assay was performed to detect the engulfment of Dil-Ac-LDL and binding to endothelial-specific lectin FITC-UEA-1 by CFs treated with mimic-218-Exo or inhibitor-218-Exo. Magnification: 120x. (b) A phagocytosis assay was performed to detect the engulfment of Dil-Ac-LDL and binding to endothelial-specific lectin FITC-UEA-1 by CFs treated with mimic-363-Exo or inhibitor-363-Exo. Magnification: 120x. (c) qRT-PCR detection of the relative expression levels of CD31, VEGFR-2, α-SMA, and vimentin in CFs treated with mimic-218-Exo or inhibitor-218-Exo. The data are presented as the mean ± SD (n = 3). ∗∗P < 0.01 and ∗∗∗P < 0.001, mimic-Exo or inhibitor-Exo versus NC-Exo. (d) qRT-PCR detection of the relative expression levels of CD31, VEGFR-2, α-SMA, and vimentin in CFs treated with mimic-363-Exo or inhibitor-363-Exo. The data are presented as the mean ± SD (n = 3). ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001, mimic-Exo or inhibitor-Exo versus NC-Exo.