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. 2021 Jul 16;2021:5591402. doi: 10.1155/2021/5591402

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Copyright © 2021 Botao Pan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ecliptae herba, wedelolactone, and quercetin inhibited proliferation and promoted apoptosis in hepatocellular carcinoma cell lines. (a) The CCK-8 assay detected the proliferation of HepG2 and Huh-7 cells treated with different concentrations of Ecliptae herba for 48 hours. (b) The CCK-8 assay detected the proliferation of HepG2 and Huh-7 cells treated with different concentrations of wedelolactone for 48 hours. (c) The CCK-8 assay detected the proliferation of HepG2 and Huh-7 cells treated with different concentrations of quercetin for 48 hours. (d) Flow cytometry detected the apoptosis of HepG2 cells with 150 μg/mL EH, 8 μg/mL wedelolactone, and 8 μg/mL quercetin treatment after Annexin-V-FITC and PI staining. (e) Flow cytometry detected the apoptosis of Huh-7 cells with 150 μg/mL EH, 8 μg/mL wedelolactone, and 8 μg/mL quercetin treatment after Annexin-V-FITC and PI staining. The data are expressed as the mean ± standard deviation values; n = 3. ^∗∗ indicates P < 0.01 and ^∗∗∗ indicates P < 0.001 compared to the control group.