Table 2.
Detailed information on 52 targets of 6 active ingredients of EH in the treatment of HCC.
| Name | Count | Gene symbol | Total |
|---|---|---|---|
| Luteolin, quercetin, wedelolactone, and HC | 2 | MMP2\MMP9 | 52 |
| Quercetin, demethylwedelolactone, 3′-O-methylorobol, and HC | 1 | ESR2 | |
| Luteolin, quercetin, and HC | 6 | EGFR\ALOX15\RELA\AKT1\GPR35\TOP1 | |
| Demethylwedelolactone, wedelolactone, and HC | 1 | GSK3B | |
| Demethylwedelolactone, 3′-O-methylorobol, and HC | 1 | ESR1 | |
| Butin, 3′-O-methylorobol, and HC | 1 | PTGS1 | |
| Luteolin and HC | 5 | MET\TYR\AR\APP\PTGS2 | |
| Quercetin and HC | 31 | XDH\PRKCB\CYP1A1\AHR\CYP19A1\MMP3\PIK3R1\CSNK2A1\PON1\MPO\ACHE\ABCG2CYP1A2\PIK3CG\TOP2A\HIF1A\INSR\NR1I2\YP3A4\HSPB1\F2\APEX1\AKR1B1\CYP1B1\ALOX5\E2F1\PIM1\PARP1\HSF1\BAX\PRKCA | |
| Demethylwedelolactone and HC | 1 | CBR1 | |
| Butin and HC | 1 | RXRA | |
| 3′-O-Methylorobol and HC | 2 | CHEK1\PRSS1 |