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. 2021 Jul 16;2021:5556212. doi: 10.1155/2021/5556212

Figure 2.

Figure 2

SFI inhibits mitochondrial dysfunction via the restoration of mitochondrial biogenesis. (a) Representative apoptosis analysis of the different time points and SFI dosages, C2C12 mouse myoblasts cells were induced by CT-26 medium for 6, 12, and 24 h and the H2O2 for 2 h. After the CT-26 medium was stimulated for 12 h, the SFI was administered using three different dosages, 5, 10, and 20 mg/mL (∗P < 0.05 vs. control, ∗∗∗∗P < 0.0001 vs. NC values represented as the mean ± SD, n = 3). (b) SFI significantly enhanced the JC-1 mitochondrial membrane (∗∗∗∗P < 0.0001 vs. CT-26 medium; values represented as the mean ± SD, n = 3) and (c) accentuated the intracellular ROS after 6 h of incubation. (d) The expression of Mn-SOD2 using western blotting analysis after the indicated treatment. The protein densitometry data were normalized with β-actin.