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. 2021 Jul 16;2021:5556212. doi: 10.1155/2021/5556212

Figure 4.

Figure 4

Network pharmacology predicted the possible compound-target interactions for SFI and CRF. (a) Venn analysis of the CRF-regulated genes and putative molecular targets of SFI. There were 244 CRF-targeted genes regulated by SFI. (b, c) The compound-target network illustrates the interactions between the active components of the SFI and CRF-targeted genes. Blue represents the compounds of the SFI, while the yellow lists the targets of the CRF genes. (d) PPI network of the SFI compound targets, different colors represent the degree, as the scale indicates. The size of the circle also indicates the degree. (e) PPI network of the SFI compound targets against CRF, the original PPI data generated from the STRING database showing the detailed interactions of the targets.