Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 22;218(9):e20210580. doi: 10.1084/jem.20210580

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Cavazzoni et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Characterization of ZIKV infection in immunocompetent BALB/c mice. (A) Experimental design indicating the time points of serum samples and lymphoid tissue collections. (B) Spleen weight measured at the time of collection, as indicated. (C and D) Total serum IgM (C) and IgG (D) from infected (ZIKV) and control (MOCK) mice, measured by ELISA. (E–G) Levels of IgM and IgG specific for viral surface antigens were measured by ELISA (1:120 dilution) using VLPs and recombinant domain III of ZIKV envelope protein (EDIII). (H and I) Levels of IgM (H) and IgG (I) specific for NS1 protein were measured by ELISA (1:120 dilution) using recombinant ZIKV NS1. Data are representative of three independent experiments with 8–16 mice per group. Statistical analyses were performed using the paired two-tailed Student’s t test. *, P ≤ 0.05; **, P ≤ 0.01. Mice from different groups were compared using the unpaired two-tailed Student’s t test. ZIKV significantly different from MOCK: m*, P ≤ 0.05; m**, P ≤ 0.01; m***, P ≤ 0.001; m****, P ≤ 0.0001. Error bars represent SEM.