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. 2021 Jul 22;218(9):e20210580. doi: 10.1084/jem.20210580

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© 2021 Cavazzoni et al.

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Figure S1. — Characterization of humoral immune response to UV-iZIKV. (A) Experimental design indicating the time points of serum samples and lymphoid tissue collections from control mice (MOCK), mice immunized with UV-inactivated virus (iZIKV), and infected mice (ZIKV). (B) Spleen weight measured at the time of collection, as indicated. (C–E) Serum levels of IgG specific to VLP (C), domain III of ZIKV envelope protein (D), and NS1 (E). Measured by ELISA at 1:120 dilution. One experiment was performed with the indicated number of mice per group. Statistical analyses were performed using the unpaired two-tailed Student’s t test. Significantly different from mock: m*, P ≤ 0.05; m**, P ≤ 0.01; m****, P ≤ 0.0001. Significantly different from iZIKV: i*, P ≤ 0.05; i****, P ≤ 0.0001. Error bars represent SEM.