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Pharmacokinetic parameters of Nuc in rats (n = 6, mean ± SD, Tmax (h) expressed as median (range))
| Parameters | Nuc |
|---|---|
| t1/2 (h) | 5.48 ± 2.54 |
| Tmax (h) | 0.5 (0.5–1) |
| Cmax (ng mL−1) | 159.39 ± 30.26 |
| AUC0-t (h* ng mL−1) | 835.54 ± 442.79 |
| AUC0-∞ (h* ng mL−1) | 858.82 ± 450.36 |
| MRT (h) | 5.20 ± 1.71 |
AUC, area under curve; Cmax, the maximum concentration; MRT, mean residence time. Tmax: median (range)
