Fig. 1.

Location of SNPs identified in Cases A, B and C in relation to the N-gene and the CDC N1- and N2-gene primers and probes. The N-gene has been highlighted in grey and the US CDC primers and probes highlighted in red and labelled above. SNPs are shown with the base substitution above and labelled, with previously described SNPs referenced [square brackets] and the novel SNPs described here highlighted. Strikethrough delineates the 4 base deletion seen in Cases A and B. Key: del, deletion; CDC, US Centers for Disease Control and Prevention; Fwd, forward primer; Pr, probe; Rev, reverse primer.