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. 2021 Jul 19;473(8):1261–1271. doi: 10.1007/s00424-021-02576-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — GABA_BR agonist-induced and antagonist-induced effects on mEPSC frequency do not depend on genotype. a Representative mEPSC traces recorded from a WT neuron demonstrate the baclofen-induced effect. b Baclofen (10 µM) significantly reduces mEPSC frequency both in WT (left) and in Tsc2^+/- (middle) neurons. Relative baclofen-induced reductions of mEPSC frequency are similar in WT and Tsc2^+/- cells (right panel). c Representative mEPSC traces recorded from Tsc2^+/- cells demonstrate the CGP55845-induced effect. d CGP55845 (1 µM) significantly increases mEPSC frequency both in WT (left) and in Tsc2^+/- (middle) cells. Relative CGP55845-induced elevations of mEPSC frequency are comparable in WT and Tsc2^+/- neurons (right panel)