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. 2021 Jul 19;473(8):1261–1271. doi: 10.1007/s00424-021-02576-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — GABA_BR agonist-induced and antagonist-induced effects on eIPSCs. a Representative eIPSC traces recorded from a WT (top) and Tsc2^+/- (bottom) cell in control and in the presence of either baclofen (10 µM) or CGP55845 (1 µM). Traces are an average of 20 consecutive recordings. b Mean eIPSC amplitudes are not significantly different in WT and Tsc2^+/- neurons. c Baclofen reduces the mean eIPSC amplitude stronger in Tcs2 ± cells compared with WT neurons (left), whereas CGP55845 increases the mean eIPSC amplitude in WT cells but not in Tsc2^+/- neurons (right panel). d In the presence of CGP55845 (CGP), the paired-pulse ratio at 500 ms interstimulus interval (PPR₅₀₀) is reduced in WT neurons (left) but increased in Tsc2^+/- ones (right panel)