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. 2021 Jul 19;473(8):1261–1271. doi: 10.1007/s00424-021-02576-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — GABA_BR agonist-induced and antagonist-induced effects on the E/I ratio at a single cell level. a Representative mEPSC (top) and mIPSC (bottom) traces recorded from the same Tsc2^+/- neuron in control (left) and in the presence of baclofen (10 µM, right panel). b Representative mEPSC (top) and mIPSC (bottom) traces of recorded from the same WT cell in control (left) and in the presence of CGP55845 (1 µM, CGP, right panel). c Statistical data shows that the E/I ratios are comparable in WT and Tsc2^+/- neurons in control (left). The baclofen-induced increase in the E/I ratio is more pronounced in Tsc2^+/- cells than in WT cells (middle). CGP55845 decreases the E/I ratio significantly stronger in WT neurons compared with Tsc2^+/- cells (right panel)