Table 1.

Metabolic and urine parameters from Wt and Sh rats. Water and food intake and urine volume were monitored in metabolic cages under baseline conditions. After adaptation, 24 h urine and blood were collected for analysis. Statistical analysis was performed using Student’s t-test (n = 6/genotype) *p < 0.05, **p < 0.01, ***p < 0.001

Parameters	Wt	Sh
Body weight (g)	303.8 ± 10.7	268.1 ± 18.7
H2O intake (g/g BW)	0.13 ± 0.01	0.13 ± 0.01
Food intake (g/g BW)	0.09 ± 0.01	0.09 ± 0.01
Plasma
pH	7.47 ± 0.01	7.51 ± 0.02
Glucose (mg/dL)	225.8 ± 22.2	206.8 ± 16.6
Na+ (mM)	136.5 ± 1.0	136.2 ± 0.3
K+ (mM)	4.37 ± 0.15	3.62 ± 0.22
Ionized Ca2+ (mM)	0.84 ± 0.14	0.80 ± 0.05
Cl− (mM)	97.8 ± 0.8	95.7 ± 0.6
Phosphate (mg/dL)	8.6 ± 0.4	9.8 ± 0.3 *
Prealbumin (mg/dL)	1.72 ± 0.31	1.53 ± 0.22
Creatinine (mg/dL)	0.30 ± 0.02	0.40 ± 0.01
BUN (mg/dL)	35.2 ± 1.0	48.3 ± 2.6 ***
Urine
Urine (g/g BW)	0.04 ± 0.01	0.03 ± 0.01
Creatinine (mg/dL)	72.2 ± 10.3	111.9 ± 13.2 *
Creatinine Clearance (mL/min)	1.9 ± 0.2	1.5 ± 0.2
Na+ (mM)/Crea (mg/dL)	95.0 ± 8.3	71.2 ± 22.8 **
K+ (mM)/Crea (mg/dL)	2.60 ± 0.11	2.73 ± 0.14
Ca2+ (mM)/Crea (mg/dL)	0.020 ± 0.003	Not detectable
Mg2+ (mg/dL)/Crea (mg/dL)	0.57 ± 0.10	0.32 ± 0.15
Phosphate (mg/dL)/Crea (mg/dL)	0.08 ± 0.08	1.71 ± 0.20 ***
Cl− (mM)/Crea (mg/dL)	2.2 ± 0.1	2.1 ± 0.1