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. 2021 Jul 23;11:15125. doi: 10.1038/s41598-021-94584-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histological analysis of organs after dual treatment with anti-VEGFR2 and anti-VEGF-A antibodies in the xenograft model. (A) Effect of treatment with anti-VEGFR2 and anti-VEGF-A antibodies on mouse kidneys. After each treatment, kidney tissues were fixed, embedded in paraffin, and stained with Periodic acid–Schiff (PAS) as described in Materials and Methods. Typical staining results in each treatment group were shown. Original magnification, ×40. (B) Effect of treatment with anti-VEGFR2 and anti-VEGF-A antibodies on mouse livers. Liver tissues were fixed, embedded in paraffin, and stained with hematoxylin and eosin (H&E) as described in Materials and Methods. Typical staining results in each treatment group were shown. The arrow indicates slight bile duct hyperplasia. Original magnification, ×10. The figures were generated by Microsoft Powerpoint (16.16.27) (https://www.microsoft.com/ja-jp/microsoft-365/powerpoint).