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. 2021 Jul 23;11:406. doi: 10.1038/s41398-021-01518-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — All the models are adjusted for the standard covariates including age, sex, age², age*sex interaction term, socioeconomic status based on Townsend deprivation index, genotyping batch, assessment centre, and the first 12 principal components of ancestry as covariates. In the model of all subjects (CVD adjusted), indicated by red colour, 3 CVD factors including statin use, CAD and parental CAD and lifestyle score are additionally adjusted. There are 53,173 statin users and 270,745 statin non-users in the data, 94,170 CVD cases and 229,104 CVD controls, and 232,286 participants with a parent with CVD and 46,914 with parents without CVD.