Table 1.
Sample characteristics.
| Total sample | Risk allele (AA, GA) | No risk allele (GG) | p | |
|---|---|---|---|---|
| (N = 25) | (n = 15) | (n = 10) | ||
| At time of study participation | ||||
| Age | 22.9 (4.7) | 23.1 (3.5) | 22.6 (6.3) | 0.06 |
| IQ | 107.3 (18.1) | 111.4 (16.5) | 103.4 (20.2) | 0.32 |
| AQ | 28.6 (9.9) | 29.9 (9.5) | 26.7 (10.6) | 0.44 |
| EQ | 25.8 (14.4) | 23.6 (12.6) | 29.2 (16.8) | 0.35 |
| ADOS SA | 9.1 (4.4) | 9.5 (4.8) | 8.6 (4.0) | 0.64 |
| ADOS RRB | 0.9 (1.0) | 0.8 (1.0) | 1.1 (1.1) | 0.49 |
| ADOS SA + RRB | 10.1 (4.6) | 10.3 (5.0) | 9.7 (4.1) | 0.77 |
| ADOS Comparison Score | 5.5 (2.6) | 5.6 (2.7) | 5.3 (2.4) | 0.78 |
| Comorbidities (ICD-10 Code) |
3 × F3 1 × F42 |
3 × F3 1 × F42 1 × F40 1 × F90 |
||
| At time of diagnosis | ||||
| Age at time of diagnosis | 13.1 (4.7) | 13.4 (4.0) | 13.1 (5.3) | 0.88 |
| ADOS SA | 11.5 (3.9) | 12.9 (3.7) | 9.5 (3.3) | 0.03 |
| ADOS RRB | 1.9 (1.5) | 2.1 (1.6) | 1.7 (1.5) | 0.50 |
| ADOS SA + RRB | 13.5 (4.9) | 15.1 (5.1) | 11.2 (3.7) | 0.06 |
| ADOS Comparison Score | 7.3 (2.1) | 8.1 (1.9) | 6.3 (2.0) | 0.03 |
| ADI-R social interaction | 17.8 (5.2) | 17.6 (5.2) | 18.3 (5.5) | 0.74 |
| ADI-R communication | 13.7 (4.6) | 13.4 (3.7) | 14.3 (5.6) | 0.62 |
| ADI-R stereotyped behavior | 5.7 (2.7) | 5.6 (3.0) | 5.8 (2.1) | 0.91 |
Means, standard deviations (in parentheses) and between-group comparisons on clinical measures in risk allele carriers and non-carriers. AQ Autism Spectrum Quotient65, EQ Empathy Quotient66, ADOS Autism Diagnostic Observational Schedule61,67, ADOS SA ADOS Social Affect Score, ADOS RRB ADOS Repetitive and Restricted Behavior Score, ADI-R Autism Diagnostic Interview-Revised62. p-values derive from two-sample t-tests comparing carriers of the risk allele A (AA, GA) to non-carriers (GG).