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. 2021 Jul 23;5:71. doi: 10.1038/s41698-021-00209-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — AUCs calculated across patient-derived ex vivo samples (columns) and 87 drugs (rows) common to OHSU (a; n = 338) and FIMM (b; n = 37) datasets. Red values correspond to higher AUC or more sensitive samples, blue are less sensitive, black are filtered, and gray are missing. Standardized AUCs (i.e., with mean zero and standard deviation one across patients) displayed in heatmap. Raw AUCs displayed in top and side panels. General response across drugs (GRD) is mean of raw AUCs for an individual patient over drugs; mean response across patients (MRP) is mean of raw AUCs for an individual drug over patients. Samples ordered by GRD in each dataset. Drugs ordered by MRP in OHSU dataset. One sample displayed per patient, with sample assayed across the highest number of drugs displayed in cases with multiple samples per patient. Class drug class, Diff/epi differentiation/epigenetic, HSP heat shock protein.