Fig. 3. Distribution of final LPC scores for six phenotypes in the test set.

LPC risk scores are derived based on all phecodes. Estimated density and distribution of LPC risk scores cases vs. controls for a CKD (cases including G1, G2, G3a/b, and G4 stages), b CAD, c T2D, d HF, e Dementia, and f GERD. For each phenotype: left, distribution of LPC risk scores in the test set. Middle, LPC risk score percentiles among cases vs. controls. Right, case prevalence in 60 bins according to the percentiles of LPC risk scores. The center line, lower and upper bounds of the box represent the median, first quartile (Q₁, or 25th percentile), and third quartile (Q₃, or 75th percentile) of the data, respectively. The whisker is drawn up (down) to the largest (smallest) observed point from the data that falls within 1.5 times the interquartile range (= Q₃ − Q₁) above (below) the Q₃ (Q₁).